In the series premiere, Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.

Alanna Blair, Ammie Montas, Anthony Ruiz, Antoinette Cirillo, Christine Chang, Donnetta Lavinia Grays, Elizabeth Cardona, Emma Ramos, Eric Martin Brown, Gary Perez, Gregory Jones, Greta Quispe, Irma Estel LaGuerre, Jason Kisare, Jay Santiago, Katherine Constanzo, Liba Vaynberg, Lisa O'Hare, Lisa Wing, Lizzy DeClement, Megan Byrne, Michael Basile, Michael Medeiros, Nathalie Carvalho, Olivia Khoshatefeh, Paula Cajiao, Raul Torres, Rose Bianco, SHukura, Stacey Raymond, Troy Iwata, Vanessa Kai, Yvette Ganier, Zabryna Guevara