Conjoined twins are among the rarest of human beings. There are probably fewer than a dozen adult pairs living in the world today. Only a few hundred pairs of conjoined twins are born in the whole world each year - they appear about once in every 100... (more),000 births - but more than half of them are stillborn, and one in three live for only a few days. Of those who survive, a very small number will be selected for separation surgery. But as there are few hospitals with the skills and experience to perform this kind of surgery, separation is still a very unusual event. The harrowing decisions which surgeons have to make when faced with conjoined twins have been highlighted by the recent case in Manchester, England. Separating conjoined twins is not only technically challenging; it can involves life and death decisions about whether one twin should be sacrificed in the hope of saving the other. But "sacrifice surgery" has a poor record of success, and the Manchester case is the latest round in an international debate about the value of separation operations. The confidence of the surgeons, who believe that separation is essential, is challenged by medical historian, Dr Alice Dreger of Michigan State University. She argues that twins themselves might take a different view - if they were ever given a chance to express it. Horizon interviews two pairs of adult conjoined twins - Lori and Reba Schappell in Pennsylvania and Masha and Dasha Krivoshlyapova in Moscow. Lori and Reba are joined at the head; Masha and Dasha are joined in their lower body. They say that they prefer their conjoined lives, despite the problems and challenges, rather than face the risks of separation surgery. Lori and Reba live independent lives in their own apartment in Pennsylvania; Lori enjoys working with computers and Reba is developing a career as a country singer. Masha and Dasha had a difficult childhood; they were subjected to medical experimentation when they were very young and hidde