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Chuck, Serena, Blair, Dan, Jenny and Eric find themselves faced with a crisis when a member of one of their families is hospitalized. Nate attempts to help his parents put their complicated past behind them and reconcile.

Benton Greene, Connor Paolo, David Call, Francie Swift, Katie Cassidy, Sam Robards, Zuzanna Szadkowski, Dan Ziskie, Stacey Yen, Tijuana Ricks