Kara turns on her friends and the citizens of National City after being exposed to Red Kryptonite makes her malicious and dangerous. Also, Cat appears on THE TALK to discuss Supergirl.

Aisha Tyler, Briana Venskus, Italia Ricci, Jenna Dewan, Julie Chen Moonves, Peter Facinelli, Sara Gilbert, Sharon Osbourne, Sheryl Underwood, Tawny Cypress