Cristina is bothered by a new year's mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison detests Derek's trailer, Derek visits Meredith's mom, George treats a young teen hermaphrodite frustr... (more)ated by her pre-pubescence. Other news includes patients doing uncanny things and relationship havoc being wrecked between the doctors, as per usual.

Becca Gardner, Jeffrey Dean Morgan, John Prosky, Joyce Guy, Kate Burton, Lauren Tom, Linda Klein, Rob Narita, Shannon Cochran