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While on vacation in Mexico, Lightman and Emily become involved in the case of a missing American woman. Back home, Foster investigates tainted blood in D.C. area hospitals with Lightman's rival, Jack Rader.

Abby Cooper, Anna Zielinski, Anthony Starke, Dale Midkiff, Erika Christensen, Jennifer Beals, Josë Zúñiga, Kamala Lopez Dawson, Larry Herron, Marc Blucas, Mary Mara, Mary Matilyn Mouser, Max Arciniega, Michael Raymond-James, Nicole DuPort, Patrick J. Adams, Ramon Fernandez, Rebecca Field, Richmond Arquette, Susanne Marques, Timothy Carhart, Tomas Arana, Victor McCay